Selected key publications 

  • Strutt H, Langton PF, Pearson N, Strutt D*, Cullen PJ*: Retromer controls planar polarity protein levels and asymmetric localisation at intercellular junctions. Current Biology 29:484-491 (2019). *joint senior/corresponding authors.

  • McGough IJ, de Groot REA, Jellett AP, Langton PF, Danson C, Heesom KJ, Sessions R, Korswagen HC*, Cullen PJ*: SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nature Communications 9:3737 (2018). *joint senior/corresponding authors.

  • Simonetti B, Danson CM, Heesom KJ, Cullen PJ: Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. Journal of Cell Biology 216(11):3695-3712 (2017).

  • McNally KE, Faulkner R, Steinberg F*, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nagele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E*, Cullen PJ*: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature Cell Biology 19(10): 1214-1225 (2017). *joint senior/corresponding authors.

  • McMillan KJ, Gallon M, Jellett AP, Clairfeuille T, McGough IJ, Danson CM, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ: Atypical Parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. Journal of Cell Biology 214, 389-399 (2016).

  • McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ: Retromer association to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Current Biology 24, 1670-1676 (2014).

 

  • Steinberg F, Gallon M, Winfield M, Thomas EC, Bell AJ, Heesom KJ, Tavaré JM, Cullen PJ: A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nature Cell Biology 15, 461-467 (2013).

 

  • Steinberg F, Heesom KJ, Bass MD, Cullen PJ: SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. Journal of Cell Biology 197, 219-230 (2012).

  • van Weering JRT, Sessions RB, Traer CJ, Kloer DP, Bhatia VK, Stamou D, Carlsson SR, Hurley JH Cullen PJ: Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J 31, 4466-4480 (2012).

 

  • Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JRT, van Heesbeen RG, Middelkoop TC, Basler K, Cullen, PJ*, Korswagen HC*: A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biology 13, 914-923 (2011). *joint senior/corresponding authors.

 

  • Wassmer T, Attar N, Harterink M, van Weering JRT, Traer CJ, Oakley JD, Goud B, Stephens DJ, Verkade P, Korswagen HC, Cullen PJ: The retromer coat complex co-ordinates endosomal sorting and dynein-mediated transport with carrier recognition by the trans-Golgi network. Developmental Cell 17, 110-122 (2009).

 

  • Traer CJ, Rutherford AC, Palmer KJ, Wassmer T, Oakley J, Carlton JG, Kremerskothen J, Stephens DJ, Cullen PJ: SNX4 coordinates endosomal sorting of transferrin receptor with dynein-mediated transport into the endocytic recycling compartment. Nature Cell Biology 9, 1370-1380 (2007).

 

  • Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford AC, Mellor H, Klumperman J, McMahon HT, Cullen PJ: Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides. Current Biology 14, 1791-1800 (2004).

 

  • Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ: Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires PI 3-kinase. Current Biology 8, 463-466 (1998).

 

  • Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF: Identification of a specific IP4-binding protein as a member of the GAP1 family. Nature (London) 376, 527-530 (1995).

Primary Peer-Reviewed Publications (most significant highlighted in bold).

 

2017:

  • Simonetti B, Danson CM, Heesom KJ, Cullen PJ: Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol 216(11):3695-3712 (2017).

  • McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nagele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol 19(10): 1214-1225 (2017).

  • Kvainickas A, Orgaz AJ, Nageke H, Diedrich B, Heesom KJ, Dengjel J, Cullen PJ, Steinberg F: Retromer/WASH dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50. J Cell Sci 130, 382-395 (2017).

  • Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I: The phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 regulates phosphoinositide 3-kinase (PI 3-kinase)-dependent integrin αIIbβ3 outside-in signalling. J Biol Chem 292, 1691-1704 (2017).

2016:

  • McMillan KJ, Gallon M, Jellett AP, Clairfeuille T, McGough IJ, Danson CM, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ: Atypical Parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol 214, 389-399 (2016).

  • Wang W, Wang X, Fujioka H, Whone AL, Caldwell MA, Cullen PJ, Liu J, Zhu X: Parkinson disease-associated mutant VPS35 causes abnormal mitochondrial dynamics through enhanced recycling of mitochondrial DLP1 complex. Nature Medicine 22, 54-63 (2016).

2015:

  • Damsa N¶, Danson CM¶, Abu-Libdel, Sharma K, Yaacov B, Coulthard E, Edvardsos S, Caldwell MA, Cullen PJ*, Elpeleg O*. A defect in SNX27, a retromer complex protein, manifesting by infantile myoclonic epilepsy and neurodegeneration. Neurogenetics 16, 215-221 (2015). ¶Joint first authors. *Joint senior/corresponding authors.

  • Gallon M, Cullen PJ: Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans 43, 33-47 (2015).

2014:

  • Gallon M, Clairfeuille T, Steinberg F, Mas C, Ghai R, Sessions RB, Teasdale RD, Collins BM, Cullen PJ: A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc Natl Acad Sci USA 111, E3604-3613 (2014).

  • McGough IJ, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom KJ, Fukuda M, Cullen PJ: Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma membrane recycling. J Cell Sci 127, 4940-4953 (2014).

  • McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ: Retromer association to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Curr Biol 24, 1670-1676 (2014).

  • Burd C, Cullen PJ: Retromer - a master conductor of endosome sorting. Cold Spring Harb Perspect Biol 6. pii:a016774 (2014).

  • van Weering JR, Cullen PJ: Membrane-associated cargo recycling by tubule-based endosomal sorting. Semin Cell Dev Biol pii:S1084-9521(14)00043-3. (2014).

2013:

  • Danson CM, Brown E, Hemmings OJ, McGough IJ, Yarwood S, Heesom KJ, Carlton JG, Martin-Serrano J, May MT, Verkade P, Cullen PJ: Sorting nexin-15 links clathrin endocytosis to the PtdIns(3)P early endosome independent of the APPL1 endosome. J Cell Sci 126, 4885-4899 (2013).

  • Hunt SD, Townley AK, Danson CM, Cullen PJ, Stephens DJ: Microtubule motors mediate endosomal sorting by maintaining functional domain organisation. J Cell Sci 126, 2493-2501 (2013).

  • Steinberg F, Gallon M, Winfield M, Thomas E, Bell AJ, Heesom KJ, Tavaré JM, Cullen PJ: A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nature Cell Biol 15, 461-471 (2013).

  • McGough IJ, Cullen PJ: Clathrin is not required for SNX-BAR-retromer mediated carrier formation. J Cell Sci 126, 45-52 (2013).

2012:

  • Cullen PJ, Korswagen HC: Sorting nexins provide diversity for retromer-dependent trafficking events. Nature Cell Biol 14, 29-37 (2012).

  • Cullen PJ, Carlton JG: Phosphoinositides in the mammalian endo-lysosomal network. T. Balla et al. (eds.), Phosphoinositides II: The diverse biological functions, Sub Biochem 59, DOI 10.1007/978-94-007-3015-1_3 (2012).

  • van Weering JRT, Sessions RB, Traer CJ, Kloer DP, Bhatia VK, Stamou D, Carlsson SR, Hurley JH Cullen PJ: Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J 31, 4466-4480 (2012).

  • Steinberg F, Heesom KJ, Bass MD, Cullen PJ: Sorting nexin-17 protects integrins from degradation by sorting between lysosomal and recycling pathways. J Cell Biol 197, 219-230 (2012).

  • Eva R, Bouyoucef-Cherchalli D, Patel K, Cullen PJ, Banting G: Inositol 1,4,5-trisphosphate 3-kinase opposes NGF driven neurite outgrowth. PLoS One 7, e32386 (2012).

  • van Weering JRT, Verkade P, Cullen PJ: SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. Traffic 13, 94-107 (2012).

2011:

  • Cullen PJ: Morton Lecture: Phosphoinositides and the regulation of tubular-based endosomal sorting. Biochem Soc Trans 39, 839-850 (2011).

  • van Weering JRT, Cullen PJ: Signaling: retromer arrests receptor on the run. Nat Chem Biol 7, 251-252 (2011).

  • Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JRT, van Heesbeen RG, Middelkoop TC, Basler K, Cullen PJ*, Korswagen HC*: A SNX3-depenent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biol 13, 914-923 (2011). *Joint senior/corresponding authors.

  • McGough IJ, Cullen PJ: Recent advances in retromer biology. Traffic 12, 963-971 (2011).

2010:

  • Nisar S, Kelly E, Cullen PJ, Mundell SJ: Regulation of P2Y1 receptor traffic by sorting nexin-1 is retromer-independent. Traffic 11, 508-519 (2010).

  • van Weering JRT, Verkade P, Cullen PJ: SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol 21, 371-380 (2010).

  • van Weering JRT, Brown E, Sharp TH, Mantell J, Cullen PJ, Verkade P: Intracellular membrane traffic at high resolution. Methods Cell Biol 96, 619-648 (2010).

  • Attar N, Cullen PJ: The retromer complex. Adv Enzyme Reg 50, 216-236 (2010).

2009:

  • Kupzig S, Bouyoucef-Cherchalli S, Yarwood S, Sessions R, Cullen PJ: The ability of GAP1IP4BP to function as a Rap1 GAP requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. Mol Cell Biol 29, 3929-3940 (2009).

  • Wassmer T, Attar N, Harterink M, van Weering JRT, Traer CJ, Oakley JD, Goud B, Stephens DJ, Verkade P, Korswagen HC, Cullen PJ: The retromer coat complex co-ordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell 17, 110-122 (2009).

2008:

  • Hara S, Kiyokawa E, Lemura S-I, Natsume T, Wassmer T, Cullen PJ, Hari H, Matsuda M: The DHR1 domain of DOCK180 binds to sorting nexin-5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell 19, 3823-3835 (2008).

  • Cullen PJ: Endosomal sorting and signalling: an emerging role for sorting nexins. Nature Rev Mol Cell Biol 9, 574-582 (2008).

  • Bujny MV, Ewels PA, Humphrey S, Attar N, Jepson MA, Cullen PJ: Sorting nexin-1 defines an early phase of Salmonella-containing vacuole remodelling during Salmonella Typhimurium infection. J Cell Sci 121, 2027-2036 (2008).

  • Mari M, Bujny MV, Zeuschner D, Geerts W, Griffth J, Petersen CM, Cullen PJ, Klumperman J, Geuze HJ: Sortilin and mannose 6-phosphate receptors define an exit from early endosomal vacuoles for SNX1-dependent recycling to the TGN. Traffic 9, 380-393 (2008).

2007:

  • Maréchal Y, Pesesse X, Jia Y, Pouillon V, Pérez-Morga D, Daniel J, Izui S, Cullen PJ, Leo O, Luo RH, Erneux C, Schurmans S. Inositol 1,3,4,5-tetrakisphosphate controls pro-apoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci USA 104, 13978-13983 (2007).

  • Traer CJ, Rutherford AC, Palmer KJ, Wassmer T, Oakley J, Carlton JG, Kremerskothen J, Stephens DJ, Cullen PJ: Sorting nexin-4 co-ordinates endosomal sorting of transferrin receptor with dynein-mediated transport into the endocytic recycling compartment. Nature Cell Biol 9, 1370-1380 (2007).

  • Bujny MV, Popoff V, Johannes L, Cullen PJ: The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network. J Cell Sci 120, 2010-2021 (2007).

  • Jin H, Wang X, Ying J, Wong AHY, Cui Y, Srivastava G, Shen Z, Li E-M, Zhang Q, Jin J, Kupzig S, Chan ATC, Cullen PJ*, Tao Q*: Epigenetic silencing of a Ca2+-regulated Ras GAP RASAL, defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci USA 104, 12353-12358 (2007). *Joint senior authors.

  • Cory GOC, Cullen PJ: Bending membranes – the power of bananas, zeppelins and boomerangs. Curr Biol 17, R455-R457 (2007).

  • Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ: A loss-of-function screen reveals sorting nexin-5 and sorting nexin-6 as potential components of the mammalian retromer. J Cell Sci 120, 45-54 (2007).

2006:

  • Yarwood S, Kupzig S, Bouyoucef-Cherchalli D, Cullen PJ: Second messenger-mediated control of Ras GTPase-activating proteins. Biochem Soc Trans 34, 846-850 (2006).

  • Cullen PJ: Coupling the spatial and temporal complexity of Ca2+ fluxes to Ras signalling. Curr Opin Cell Biol 18, 157-161 (2006).

  • Rutherford AC, Traer CJ, Wassmer T, Pattni K, Bujny MV, Carlton JG, Stenmark H, Cullen PJ: The mammalian phosphatidylinositol 3 monophosphate 5-kinase PIKfyve regulates endosome-to-TGN retrograde transport. J Cell Sci 119, 3944-3957 (2006).

  • Kupzig S, Deaconescu D, Bouyoucef-Cherchalli D, Walker SA, Liu Q, Polte CL, Daumke O, Ishizaki T, Lockyer PJ, Wittinghofer A, Cullen PJ: GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem 281, 9891-9900 (2006).

2005:

  • Carlton JG, Bujny MV, Peter BJ, Oorschot VMJ, Rutherford AC, Arkell RS, Klumperman J, McMahon HT, Cullen PJ: Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci 118, 4527-4539 (2005).

  • Liu Q, Walker SA, Gao D, Taylor JA, Dai Y-F, Arkell RS, Bootman MD, Roderick HL, Cullen PJ, Lockyer PJ: CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. J Cell Biol 170, 183-190 (2005).

  • Kupzig S, Bouyoucef D, Cozier GE, Cullen PJ: Studying the spatial and temporal regulation of Ras GTPase-activating proteins. Methods Enzymol 407, 64-82 (2005).

  • Kupzig S, Walker SA, Cullen PJ: The frequencies of Ca2+ oscillations are optimised for efficient Ca2+-mediated activation of Ras and the ERK/MAPK cascade. Proc Natl Acad Sci USA 102, 7577-7582 (2005).

  • Carlton JG, Cullen PJ: Sorting nexins – a commentary. Curr Biol 15, R819-R820 (2005).

  • Carlton JG, Cullen PJ: Co-incidence detection in phosphoinositide signalling. Trends Cell Biol 15, 540-547 (2005).

  • Carlton JG, Bujny MV, Rutherford AC, Cullen PJ: Sorting nexins – Unifying trends and new perspectives. Traffic 6, 75-82 (2005).

2004:

  • Carlton JG, Bujny MV, Peter BJ, Oorschot VMJ, Rutherford AC, Mellor H, Klumperman J, McMahon HT, Cullen PJ: Sorting nexin-1 mediates tubular endosome-to-TGN transport through co-incidence sensing of high curvature membranes and 3-phosphoinositides. Curr Biol 14, 1791-1800 (2004).

  • Cozier GE, Carlton JG, Bouyoucef D, Cullen PJ: Modular pleckstrin homology domains in phosphoinositide-mediated membrane targeting. Curr Topics Microbiol Immunol 282, 49-88 (2004).

  • Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona T, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ: Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J 23, 1749-1760 (2004).

  • Walker SA, Cozier GE, Cullen PJ: GFP fusion proteins to study signalling in live cells. Methods Mol Biol 273, 407-420 (2004).

  • da Silva Xavier G, Qian Q, Cullen PJ, Rutter GA: Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic β-cell glucose sensing revealed by RNA silencing. Biochem J 377, 149-158 (2004).

2003:

  • Cozier GE, Bouyoucef D, Cullen PJ: Engineering the phosphoinositide-binding profile of a Group I pleckstrin homology (PH) domain. J Biol Chem 278, 39489-39496 (2003).

  • Bivona T, Perez de Castro I, Ahearn I, Grana T, Lockyer PJ, Nell B, Cullen PJ, Pellicer A, Cox A, Philips MR: PLCγ activates Ras on Golgi via RasGRP1. Nature (London) 424, 694-698 (2003).

  • Cullen PJ: Calcium signalling: The Ups and Downs of protein kinase C. Curr Biol 13, R699-R701 (2003).

  • Walker SA, Lockyer PJ, Cullen PJ: The Ras binary switch – an idea processor for decoding complex calcium signals? Biochem Soc Trans 31, 966-969 (2003).

  • Walker SA, Cullen PJ, Taylor JA, Lockyer PJ: Control of Ras cycling by calcium. FEBS Lett 546, 6-10 (2003).

2002:

  • Cozier GE, Carlton J, McGregor AH, Gleeson PA, Teasdale RD, Mellor H, Cullen PJ: The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J Biol Chem 277, 48730-48736 (2002).

  • Walker SA, Kupzig S, Lockyer PJ, Bilu S, Zharhary D, Cullen PJ: Analysing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular calcium homeostasis. J Biol Chem 277, 48764-48770 (2002).

  • Cullen PJ, Lockyer PJ: The integration of Ca2+ and Ras signalling. Nat Rev Mol Cell Biol 3, 339-348 (2002).

2001:

  • Bobe R, Wilde J, Maschberger P, Venkateswarlu K, Cullen PJ, Siess W, Watson SP: PI 3-kinase dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Btk translocation. Blood 97, 678-684 (2001).

  • Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A: Casein kinase Iα associates with members of the centaurin-α family of PIP3-binding proteins. J Biol Chem 276, 18757-18764 (2001).

  • Lockyer PJ, Kupzig S, Cullen PJ: CAPRI regulates Ca2+-dependent inactivation of the Ras-MAP kinase pathway. Curr Biol 11, 51-56 (2001).

  • Cullen PJ: Ras effectors – Buying shares in Ras plc. Curr Biol 11, R342-R344 (2001).

  • Cullen PJ, Cozier GE, Banting G, Mellor H: Phosphoinositide-binding modular protein domains – their role in signalling and membrane trafficking. Curr Biol 11, R882-R893 (2001).

2000:

  • Venkateswarlu K, Cullen PJ: Signalling via ADP-ribosylation factor 6 lies downstream of PI 3-kinase. Biochem J 345, 719-724 (2000).

  • Cozier G, Sessions R, Bottomley JR, Reynolds JS, Cullen PJ: Molecular modelling and site-directed mutagenesis of the IP4-binding PH domain from the Ras GTPase-activating protein GAP1IP4BP. Biochem J 349, 333-342 (2000).

  • Cozier GE, Lockyer PJ, Reynolds JS, Kupzig S, Bottomley JR, Millard T, Banting G, Cullen PJ: GAP1IP4BP contains a novel Group I pleckstrin homology domain that directs constitutive plasma membrane association. J Biol Chem 275, 28261-28268 (2000).

  • Millard T, Cullen PJ, Banting G: The effects of elevated expression of IP3 3-kinase B on Ca2+ homeostasis in HeLa cells. Biochem J 352, 709-715 (2000).

  • Cullen PJ, Chardin P: Membrane targeting – What a difference a G makes. Curr Biol 10, R876-R878 (2000).

1999:

  • Venkateswarlu K, Cullen PJ: Molecular cloning and functional characterisation of a human homologue of centaurin-α. Biochem Biophys Res Commun 262, 237-244 (1999).

  • Lockyer PJ, Vanlingen S, Reynolds JS, McNulty TJ, Irvine RF, Parys JB, Cullen PJ: Tissue specific expression and endogenous subcellular distribution of the IP4-binding proteins GAP1IP4BP and GAP1m. Biochem Biophys Res Commun 255, 421-426 (1999).

  • Venkateswarlu K, Oatey PB, Tavaré JM, Jackson TR, Cullen PJ: Identification of centaurin-α1 as an in vivo PIP3-binding protein that is functionally homologous to the yeast ARF GTPase-activating protein Gcs1. Biochem J 340, 359-363 (1999).

  • Oatey PB, Venkateswarlu K, Williams AG, Fletcher LM, Foulstone EJ, Cullen PJ, Tavaré JM: Confocal imaging of the subcellular distribution of PIP3 in insulin- and PDGF-stimulated 3T3-L1 adipocytes. Biochem J 344, 511-518 (1999).

  • Venkateswarlu K, Gunn-Moore F, Tavaré JM, Cullen PJ: EGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J Cell Sci 112, 1957-1965 (1999).

  • Lockyer PJ, Wennström S, Venkateswarlu K, Downward J, Cullen PJ: Identification of the Ras GTPase-activating protein GAP1m as an in vivo PIP3-binding protein. Curr Biol 9, 265-268 (1999).

  • Cullen PJ, Venkateswarlu K: The potential regulation of ARF6 signalling by PIP3. Biochem Soc Trans 27, 683-690 (1999).

1998:

  • Cullen PJ: Bridging the GAP in IP4 signalling. Biochim Biophys Acta 1436, 35-47 (1998).

  • Loomis-Husselbee JW, Walker CD, Bottomley JR, Cullen PJ, Irvine RF, Dawson AP: Modulation of inositol 2,4,5-trsiphosphate-stimulated Ca2+ release by IP4; enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative IP4 receptor. Biochem J 331, 947-952 (1998).

  • Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ: Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires PI 3-kinase. Curr Biol 8, 463-466 (1998).

  • Venkateswarlu K, Gunn-Moore F, Oatey PB, Tavaré JM, Cullen PJ: NGF- and EGF-stimulated translocation of the ARF-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of PI 3-kinase and the GRP1 PH domain. Biochem J 335, 139-146 (1998).

  • Bottomley JR, Reynolds JS, Lockyer PJ, Cullen PJ: Structural and functional analysis of the putative IP4 receptors GAP1IP4BP and GAP1m. Biochem Biophys Res Commun 250, 143-149 (1998).

1997:

  • Soriano S, Thomas S, High S, Griffths G, D’Santos C, Cullen PJ, Banting G: Membrane association, localisation and topology of rat IP3 3-kinase B: implications for membrane traffic and Ca2+ homeostasis. Biochem J 324, 579-589 (1997).

  • Cullen PJ, Loomis-Husselbee JW, Dawson AP, Irvine RF: IP4 and calcium homeostasis - the role of GAP1IP4BP. Biochem Soc Trans 25, 991-996 (1997).

  • Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BVL, Dempsey CE, Cullen PJ: Distinct subcellular localisations of the putative IP4 receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Curr Biol 7, 1007-1010 (1997).

1996:

  • Loomis-Husselbee JW, Cullen PJ, Dreikhausen UE, Irvine RF, Dawson AP: Synergistic effects of IP4 on inositol 2,4,5-trisphosphate-stimulated Ca2+ release do not involve direct interactions of IP4 with IP3-binding sites. Biochem J 314, 811-816 (1996).

  • Irvine RF, Cullen PJ: Intracellular signalling - Inositol phosphates - Whither bound? Curr Biol 6, R537-540 (1996).

1995:

  • Cullen PJ, Dawson AP, Irvine RF: Purification and characterisation of an IP4-binding protein from pig platelets: possible identification of a novel non-neuronal IP4 receptor. Biochemical Journal 305, 139-143 (1995).

  • Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF: Identification of a specific IP4-binding protein as a member of the GAP1 family. Nature (London) 376, 527-530 (1995).

  • Cullen PJ, Chung S-K, Chang Y-T, Dawson AP, Irvine RF: Specificity of the purified IP4-binding protein from porcine platelets. FEBS Letters 358, 240-242 (1995).

1994:

  • Cullen PJ, Patel Y, Kakkar VV, Irvine RF, Authi KS: Specific binding sites for IP4 are located predominantly in the plasma membrane of human platelets. Biochemical Journal 298, 739-742 (1994).

  • Thastrup O, Dawson AP, Scharff O, Foder B, Cullen PJ, Drøbak BK, Bjerrum PJ, Christensen SB, Hanley MR: Thapsigargin, a novel molecular probe for studying intracellular Ca2+ release and storage. Agents and Action 43, 187-193 (1994).

1993:

  • Irvine RF, Cullen PJ: Will the real IP4 receptor please stand up? Curr Biol 3, R540-R543 (1993).

1992:

  • Cullen PJ, Irvine RF: IP4-binding sites in neuronal and non-neuronal tissues: properties, comparisons and potential physiological significance. Biochemical Journal 288, 149-154 (1992).

1991:

  • Loomis-Husselbee JW, Cullen PJ, Irvine RF, Dawson AP: Electroporation can cause artefacts due to solubilisation of cations from the electrode plates. Aluminium ions enhance the conversion of IP4 into IP3 in electroporated L1210 cells. Biochem J 277, 883-885 (1991).

1990:

  • Cullen PJ, Irvine RF, Dawson AP: Synergistic control of Ca2+ mobilisation in permeabilised mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and IP4. Biochem J 271, 549-553 (1990).

  • Thastrup O, Cullen PJ, Drøbak BK, Hanley MR, Dawson AP: Thapsigargin has a novel mechanism of action among tumour promoters: discharge of intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase. Proc Natl Acad Sci USA 87, 2466-2470 (1990).

  • Shears SB, Dawson AP, Loomis-Husselbee JW, Cullen PJ: The perturbation, by aluminium, of receptor-generated Ca2+ transients in hepatocytes is not due to effects of IP3-stimulated Ca2+ release or IP3 metabolism by the 3-kinase or 5-phosphatase. Biochem J 270, 837-838 (1990).

1989:

  • Cullen PJ, Irvine RF, Drøbak BK, Dawson AP: IP4 causes release of Ca2+ from permeabilised mouse lymphoma L1210 cells by its conversion into IP3. Biochem J 259, 931-933 (1989).

  • Thastrup O, Dawson AP, Scharff O, Foder B, Cullen PJ, Drøbak BK, Bjerrum PJ, Christensen SB, Hanley MR: Thapsigargin, a novel molecular probe for studying intracellular Ca2+ release and storage. Agents and Action 27, 17-23 (1989).

1988:

  • Cullen PJ, Comerford JG, Dawson AP: Heparin inhibits the IP3-induced Ca2+ release from rat liver microsomes. FEBS Letters 228, 57-59 (1988).